I look at 2 things from KenPom: Adjusted Offense and Adjusted Defense. Basically, this is efficiency without respect to tempo. Within that, I believe that D rating is more important but that O rating must show that you've got enough firepower to get the job done.
Here is where the main contenders rate (teams that are likely top seeds):
KenPom Rank | Team | AdjD | AdjO |
1 | Virginia | 1 | 37 |
2 | Villanova | 32 | 1 |
3 | Duke | 14 | 2 |
4 | Purdue | 17 | 4 |
5 | Michigan State | 7 | 10 |
6 | Cincinnati | 2 | 45 |
7 | Gonzaga | 23 | 12 |
8 | North Carolina | 58 | 3 |
9 | Kansas | 42 | 9 |
10 | West Virginia | 30 | 15 |
11 | Auburn | 36 | 14 |
12 | Texas Tech | 3 | 51 |
13 | Tennessee | 4 | 49 |
14 | Xavier | 68 | 7 |
15 | Michigan | 12 | 35 |
16 | Ohio State | 15 | 31 |
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When I look deeper at those numbers, I still like Virginia a lot. UVA's D is crazy good. The difference between them and #3 D Texas Tech is 8.3. That's absolutely insane. It's greater than the difference between #3 and #65. (#2 Cincinnati is also elite, but is 4.2 behind UVA). Only question with Virginia is if they have enough firepower to overcome a team that gets hot from 3.
Villanova's performance on O is also #1 with a bullet, ranking 3.8 above #2 Duke. So that's a team that could get hot and win it just as they did a couple years ago. But it is hard to win that way and unlikely.
Ideally, I want to see a Top 10 defense with a Top 20 offense. The only team that fits that description is Michigan State -- and they're top 10 in both. But since I can't stomach rooting for them, I won't be picking them. On the numbers alone I would, though.
Duke and Purdue are also very solid picks, by the numbers. And if you believe in defense, look out for Cincinnati, Texas Tech or Tennessee to make a run to the Final Four like South Carolina did despite their lack of firepower.