I think it would be a mistake to blame our problems on scheme and therefore rule out people who use such schemes. I saw the comments by some CU players talking about complicated reads, etc., but that's a function of the specific way the scheme is used and implemented. There are variations galore out there for all of these approaches (my goodness, look at all the variations of the spread offense).
In fact, given that the players we have were recruited for a pro-style, it might not be bad to use it. The difference is in playcalling and execution. I mean, the "pro style offense" didn't call a QB sneak on a 1st and 10 down...
Schools (even small schools) have been running that offense forever (Oregon was running a variation of it in the 1980s). Block well...tackle well...have a play caller upstairs with some creativity and touch...it can work just fine (in fact...I'm not sure that most offenses can't if implemented and executed correctly). The spread is hot right now...but college football is like that. Offenses get trendy and then get replaced by newer trendy ones. But switching to, say, the spread doesn't do anything magical for you (especially if you don't have the right sort of players recruited to play in it) anymore than switching to the I-Bone does. They all have their pros and cons...and all only work if you play fundamentally, are well coached, and the right calls are made by either the OC or the signal caller.
And there's nothing wrong with the 4-3 either. I prefer the 3-4 myself...but they all can work (the 4-2-5 is good too...works well against spread teams allegedly. But then you play against USC and Stanford and there goes your advantage in scheme...).
The problem at Colorado was bad coaching...poor fundamentals...bad play calling...not enough raw talent on the field...and not enough "coaching up" of the talent we DID field. The defensive or offensive scheme we chose to run was a convenient whipping boy...but it played virtually no role in what happened on the field with us (to believe that, you would have to think if we just switched schemes, we would have magically improved significantly).
The SJSU coach's schemes will work just fine if he can do a good job coaching.