If you go the workhorse route, you better have a very good offensive line and fullbacks that can punch it in from 10 yards out. It's a lot easier to pick up 5-6 yards per carry from your own 30 yard line than it is from inside the opponent's 10. You also better have some good special teams, because you'll always be playing the field position game.
Not that any of that is bad, but it's important to know what components you need to compliment the skill position players you have.
The opposite side of that is that if your offense is predicated on explosive plays rather than ball control, you better be more talented than the teams you are playing or you'll be shut down and your defense will be on the field for 40 minutes.
I think that we're much more likely to be able to implement the Wisconsin and Stanford models at CU than the Florida (Urban era) and Oregon models.
Even Florida under Urban didn't work all that well when they had to go up against the top teams, even with Tebow giving them the ability to run power with a QB for ball control and short yardage. Oregon similarly struggled with LSU and USC last season.